Table 2.

Summary of chemokine receptor function in GBM tumorigenic processes and in GBM cell subtypes. Legend: TAMs: tumor-associated macrophages; TILs: tumor-infiltrating lymphocytes; IV: evidence from in vitro experiments (GSCs and others); P: evidence from patient tissue; ?: still debated.

Role in		CCR1	CCR5	CCR6	CCR10	CX3CR1	CXCR2	CXCR4	ACKR1	ACKR2	ACKR3
Processes	Angiogenesis			IV			P	P			P
	Invasion		IV				IV	P			?
	Stem cell properties						IV	P			?
	Resistance		IV				IV	P
Cell types	Tumor cells							P			P
	Vascular cells							P			P
	TAMs/Microglia		P			P		P
	TILs		P	P				P
	Neutrophils						P
	Normal glial cells							P			P