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. 2021 Dec 22;14(1):27. doi: 10.3390/cancers14010027

Table 1.

Cyclocreatine (cCr) IC50 values in PyMT ER-negative cells. IC50 values ± SEM were determined at 96 h, as described in the Materials and Methods section. IC50 values for independent experiments were calculated using non-linear regression and variable slope fit in Prism 9.0. Results from independent experiments were averaged to report the mean (n = 6, WT; n = 6, HIF-1 KO; n = 4, EV; n = 6, sh61).

HIF-1 WT HIF-1 KO EV sh61 CKB KD
16.76 mM ± 4.47 15.44 mM ± 3.95 13.73 mM ± 4.33 16.43 mM ± 2.98