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Combination indices calculated for human TNBC cell lines pairing cCr with either Taxol or DOX. Isobole studies were performed, and data representative of 2 independent isobole assays are shown.
| TNBC Models | Taxol @ IC50 +cCr @ IC30 Combination Indices (CI) |
DOX @ IC50 +cCr @ IC30 Combination Indices (CI) |
||
|---|---|---|---|---|
| Cell Line | IC50, TAXOL CI |
IC70, TAXOL CI |
IC50, DOX CI |
IC70, DOX CI |
| MDA-MB-468 | 1.06 | 0.52 | 0.61 | 0.39 |
| BT549 | 0.86 | 0.58 | 1.50 | 1.28 |
| MDA-MB-453 | 0.95 | 2.18 | 0.77 | 1.40 |
