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. 2021 Dec 21;14(1):3. doi: 10.3390/cancers14010003

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Top ten differentially expressed genes differentiate nevi and melanoma. Differentially expressed genes from each of the pairwise comparisons between the lesions were ranked based on Benjamini–Hochberg-adjusted p-values (absolute log₂(FC) ≥ 1.5; Benjamini–Hochberg-adjusted p-value < 0.05; False discovery rate = 5%). Hierarchical clustered heatmap and principal components analysis with the top ten differentially expressed genes for (A,B) benign nevi (BN), dysplastic nevi (DN), and cutaneous malignant melanoma (CMM) in the Krueger dataset; (C,D) BN, DN, radial growth phase melanoma (RGM), and vertical growth phase melanoma (VGM) in the Scatolini dataset; and (E,F) progressing nevi (PN) and CMM for the Bastian dataset. FC, fold change.