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. 2021 Dec 25;14(1):96. doi: 10.3390/cancers14010096

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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New molecular prognostic classification for uveal melanoma based on the data generated by the TCGA project involving primary uveal melanoma cases [40]. The new model comprises four main prognostic classes: class A [D3/D8], class B (D3/partial extra 8q), class C (M3/8q gain) and class D (M3/multiple 8q gains). The risk of metastases development increases progressively from class A to class D. Uveal melanoma patients in class D have the least favourable prognosis, with nearly all patients dying within the first decade after diagnosis. Diagram generated in line with previous literature [3,36,39,40,73] (Diagram created with BioRender.com, accessed on 15 December 2021).