. 2021 Dec 28;14(1):127. doi: 10.3390/cancers14010127

Table 2.

Factors associated with toxicity and early death and unplanned hospitalizations.

Variable	Toxicity G3–4			Early Death			Unplanned Hospitalizations
Variable	No	Yes	p Value	No	Yes	p Value	No	Yes	p Value
ECOG PS			0.95			0.91			0.031
2	9	4		10	3		6	7
0–1	133	69		158	44		149	53
IADL			0.04	9672		0.20			0.0001
≤7	85	33			22		98	20
8	57	40			25		57	40
ADL			0.85			0.038			0.004
≤5	22	12		22	12		16	18
6	120	61		146	35		139	42
Charlson comorbidity score			0.56			0.008			0.015
≥2	45	26		48	23		58	12
0–1	97	47		120	26		96	482
Unintentional weight loss %			0.012			0.000			0.0001
>5%	40	33		40	33		37	36
≤5%	102	40		128	14		118	24
Creatinine Clearance mL/min			0.022			0.26			0.0001
<50	42	33		60	21		36	46
≥50	100	40		108	26		119	14
Albumin g/dL			0.17			0.000			0.51
≤35	24	18		23	19		32	10
>35	118	55		145	28		123	50
Hemoglobin (g/dL)			0.61			0.02			0.48
<11	27	16		28	15		32	15
≥11	1157	57		140	32		123	45
Metastatic status			0.49			0.000			0.000
M1	67	38		69	36		64	41
M0	75	35		99	11		91	19
Chemotherapy			0.37			0.96			0.37
Standard therapy	63	37		78	22		75	25
Reduced/monotherapy	79	36		90	25		80	35
MAX2 index			0.03			0.73			0.84
≥0.45	87	55		110	32		103	39
0–0.44	55	18		58	15		52	21

Abbreviations: ECOG PS: Eastern Cooperative Oncology Group performance status, ADL: Activity of Daily Living, IADL: Instrumental activity of Daily Living.