Table 3.

Variables significantly associated with toxicity grade 3–5.

Variable	β	SE	p †	HR (95% CI)	Score
MAX2 index > 0.45	0.796	0.315	0.009	2.176 (1.143–4.213)	2
Weight loss > 5%	0.709	0.315	0.03	2.014 (1.084–3.969)	2
IADL ≤ 7	0.455	0.284	0.04	1.293 (1.013–2.318)	1
Creatinine Clearance < 50 mL/min	0.628	0.299	0.03	1.891 (1.061–3.384)	1

SE: Standard error, CI: confidence interval, HR: hazard ratio, p † values were calculated using a two-sided Wald test for multivariable analyses. IADL: Instrumental activity of Daily Living.