Figure 2.

Influence of the molecular subtype on the engraftment sites. All 101 animals used for cell expansion irrespective of the engraftment passage were considered for these analyses. (A,B) Bone marrow and spleen infiltration were determined by a flow cytometric analysis of human C45⁺/CD19⁺, C45⁺/CD5⁺ and CD45⁺/CD7⁺ blasts isolated from animals at the end of the expansion experiment. Kruskal–Wallis and post-hoc Dunn’s multiple comparisons test. (C) Influence of the molecular subtype on the spleen weight. Kruskal–Wallis test. (D,E) Correlation analysis between the spleen weight and spleen infiltration (D) and spleen and bone marrow blast frequency (E). Each dot represents a single animal, and mice engrafted with the same patient material are displayed in the same color. Similar color shades indicate the same molecular subtype. Spearman’s correlation value r.