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Schematic view of ECM organization (based on [12,17,18]). The major components of the basement membrane are the network-forming collagens (type IV collagen) and laminins. Nidogens and perlecan serve as binding bridges between the two networks: nidogens bridge laminin and collagen IV networks, and perlecan connects nidogen to collagen IV. Collagen VI interact with collagen IV, providing a link between the basement membrane and fibrillar components of the interstitial matrix.
