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. 2021 Dec 27;11(1):61. doi: 10.3390/cells11010061

Figure 1.

Figure 1

PXR structure (a) and activation following ligand binding (b). Upon ligand binding, PXR enters the nucleus and forms a complex with RXR. The recruitment of the coactivators HAT and SRC-1 into the complex further promotes PXR binding to DNA response elements, allowing the entrance of RNA polymerase II that starts gene transcription. HDAC downregulates PXR transcriptional activity. Abbreviations: DNA-binding domain (DBD), ligand-binding region (LBD), steroid receptor coactivator-1 (SRC-1), retinoid X receptor (RXR), histone acetyltransferase (HAT), histone deacetylase (HDAC).