Table 3.

Main studies investigating the involvement of PXR in liver fibrosis.

Effect	Model	Reference
PXR activators inhibit HSC differentiation and reduce hepatic inflammation and fibrosis	Human myofibroblasts and SJL/J mice	[10]
Decrease in PXR expression	Mice treated with thioacetamide or fed with a high-fat–cholesterol (HFC) diet	[12]
PCN-induced PXR activation decreases fibrogenesis by downregulating TGF–β1 pathway and HSC transdifferentiation	Mice with CCl4-induced fibrosis	[86]
Decrease in PXR expression in end-stage liver disease, correlated with the downregulation of GSTA1 and CAR	Patients with end-stage liver disease of various etiologies	[87]
Decrease in PXR expression	Patients with viral hepatitis and fibrosis	[88,89]