Table 3.

GI₅₀ and relative GI₅₀ values (CGI) for cisplatin, lomustine, and topotecan in combination with HDAC inhibitors (SAHA: 0.3 μM, TSA: 0.03μM, 2a: 5 μM, 1a and 2a–5c: 50 μM) in SiSo cells [mean ± SD of $n>3$]. Statistical significant values are shown in boldface while background colors were applied for easier visualization.

	Cisplatin		Lomustine		Topotecan
	GI50 (μM)	CGI	GI50 (μM)	CGI	GI50 (μM)	CGI
W/O	237.9	1.000	4.93	1.000	20.15	1.000
	60.8		0.61		2.03
SAHA	156.3	0.805	4.90	0.948	16.31	0.634
	18.2	0.070	0.36	0.023	1.26	0.318
TSA	177.5	0.914	5.15	0.995	16.52	0.804
	25.6	0.103	0.50	0.045	0.94	0.032
1a	134.9	0.428	2.40	0.495	13.54	0.700
	50.9	0.072	0.28	0.074	0.58	0.050
2a	184.2	0.875	4.10	0.853	10.03	0.518
	13.7	0.066	0.99	0.069	0.59	0.029
3a	189.7	0.606	2.31	0.473	11.20	0.578
	70.8	0.112	0.40	0.055	0.80	0.029
4a	265.3	0.855	4.05	0.828	14.64	0.754
	64.4	0.053	0.70	0.092	1.44	0.041
5a	120.6	0.566	2.85	0.591	12.83	0.659
	31.8	0.089	0.72	0.042	1.68	0.035
5b	308.0	1.002	5.18	1.068	18.84	0.967
	47.5	0.025	0.76	0.164	2.68	0.039
5c	275.3	0.890	4.56	0.929	15.44	0.790
	55.0	0.048	0.72	0.039	3.12	0.074