Table 2.
Characteristics of HIV-cHL patients with matched controls at cHL diagnosis.
| Populations | p-Values * | |||
|---|---|---|---|---|
| cHL Patients (n = 14) | Controls (n = 14) | |||
| Age | 0.0006 | |||
| Median | 46 | 51 | ||
| IQR | 41–52 | 44–55 | ||
| Sex | 1 | |||
| M | 12 | 12 | ||
| F | 2 | 2 | ||
| HIV viral Load (copies/mL) | 1 | |||
| ≤200 | 13 | 12 | ||
| >200 | 1 | 2 | ||
| Serum Markers | ||||
| IgG levels (g/L) | 0.31 | |||
| Median | 13.2 | 13.3 | ||
| IQR | 12.1–16.5 | 10.1–15.6 | ||
| n | 14 | 14 | ||
| IgA levels (g/L) | 0.19 | |||
| Median | 3.2 | 2.2 | ||
| IQR | 1.6–4.0 | 1.7–2.6 | ||
| n | 14 | 14 | ||
| IgM levels (g/L) | 0.49 | |||
| Median | 0.8 | 0.6 | ||
| IQR | 0.5–1.1 | 0.4–1.0 | ||
| n | 14 | 14 | ||
| IL10 (pg/mL) | <0.0001 | |||
| Median | 22.4 | 4.5 | ||
| IQR | 11.2–54.4 | 3.9–7.5 | ||
| n | 14 | 14 | ||
| IL6 (pg/mL) | 0.002 | |||
| Median | 23.5 | 2.1 | ||
| IQR | 5.2–128.7 | 0.9–9 | ||
| n | 14 | 14 | ||
| BAFF (pg/mL) | <0.0001 | |||
| Median | 898.9 | 398.8 | ||
| IQR | 720.2–1790.3 | 323.2–445.4 | ||
| n | 14 | 14 | ||
| Lymphocytic subpopulations | ||||
| CD45+ Lymphocytes | 0.63 | |||
| (cells/μL) | Median | 1488 | 1629 | |
| IQR | 966–2570 | 1203–2086 | ||
| n | 14 | 14 | ||
| CD3+CD4+ T-cells | 0.39 | |||
| (cells/μL) | Median | 498.5 | 417.5 | |
| IQR | 328–579 | 386–558 | ||
| n | 14 | 14 | ||
| CD3+CD8+ T-cells | 0.33 | |||
| (cells/μL) | Median | 616.5 | 646.5 | |
| IQR | 415–1208 | 431–741 | ||
| n | 14 | 14 | ||
| CD19+ B-cells | 0.91 | |||
| (cells/μL) | Median | 165 | 170.5 | |
| IQR | 87–210 | 125–222 | ||
| n | 14 | 14 | ||
| %CD27−IgD+ CD19+ naive B-cells | 0.0005 | |||
| Median | 76.2 | 53.1 | ||
| IQR | 64.7–89.1 | 38.3–62.2 | ||
| n | 12 | 12 | ||
| %CD27+IgD+ in CD19+ marginal zone-type B-cells | 0.62 | |||
| Median | 5.5 | 11.5 | ||
| IQR | 4.1–20.5 | 5.6–14.1 | ||
| n | 12 | 12 | ||
| %CD27+IgD− in CD19+ memory B-cells | 0.0005 | |||
| Median | 6.7 | 25.2 | ||
| IQR | 1.8–11.5 | 20.5–32.2 | ||
| n | 12 | 12 | ||
| CD56+CD16+ NK-cells | 0.17 | |||
| (cells/μL) | Median | 143.5 | 247.5 | |
| IQR | 81–258 | 125–406 | ||
| n | 14 | 14 | ||
* p values were determined by the McNemar test (categorical variables) or the Wilcoxon signed-rank test (continuous variables). cHL: classical Hodgkin lymphoma; IQR: interquartile range; NK: natural killer.