Table 4.
Comparison of lymphocyte subsets and serum marker levels collected at HIV- cHL diagnosis and 24 months after.
| At cHL Diagnosis (n = 38) | At 24 Months (n = 38) | p-Value * | ||
|---|---|---|---|---|
| Serum Markers | ||||
| IL10 (pg/mL) | <0.0001 | |||
| Median | 36.4 | 7.2 | ||
| IQR | 17.5–75.4 | 4.2–13.0 | ||
| n | 37 | 37 | ||
| IL6 (pg/mL) | 0.0002 | |||
| Median | 28.0 | 4.1 | ||
| IQR | 8.1–60.5 | 1.9–14.4 | ||
| n | 37 | 37 | ||
| BAFF (pg/mL) | <0.0001 | |||
| Median | 2043.8 | 527.0 | ||
| IQR | 932.2–4288.9 | 390.8–674.6 | ||
| n | 37 | 37 | ||
| IgG levels (g/L) | <0.0001 | |||
| Median | 14.1 | 11.8 | ||
| IQR | 11.3–18.0 | 10.0–12.9 | ||
| n | 37 | 37 | ||
| IgA levels (g/L) | ||||
| Median | 2.9 | 2.5 | 0.0003 | |
| IQR | 1.6–4.3 | 1.7–3.0 | ||
| n | 37 | 37 | ||
| IgM levels (g/L) | 0.03 | |||
| Median | 0.6 | 0.5 | ||
| IQR | 0.4–1.1 | 0.4–0.8 | ||
| n | 37 | 37 | ||
| Lymphocytic subpopulations | ||||
| CD3+CD4+ T-cells | <0.0001 | |||
| (cells/μL) | Median | 267 | 490 | |
| IQR | 125–510 | 330–681 | ||
| n | 38 | 38 | ||
| CD3+CD8+ T-cells | 0.01 | |||
| (cells/μL) | Median | 496 | 787 | |
| IQR | 325–788 | 575–1027 | ||
| n | 38 | 38 | ||
| CD19+ B-cells | <0.0001 | |||
| (cells/μL) | Median | 56 | 302 | |
| IQR | 16–153 | 247–362 | ||
| n | 38 | 38 | ||
| %CD27−IgD+ in CD19+ naive B-cells | <0.0001 | |||
| Median | 78.4 | 89.6 | ||
| IQR | 66.0–86.7 | 84.9–93.7 | ||
| n | 31 | 31 | ||
| %CD27+IgD+ in CD19+ marginal zone-type B-cells | <0.0001 | |||
| Median | 5.1 | 2.3 | ||
| IQR | 3.0–10.7 | 1.1–3.4 | ||
| n | 31 | 31 | ||
| %CD27+IgD− in CD19+ memory B-cells | 0.01 | |||
| Median | 6.9 | 4.8 | ||
| IQR | 2.4–11.7 | 3.2–8.1 | ||
| n | 31 | 31 | ||
| CD56+CD16+ NK-cells | <0.0001 | |||
| (cells/μL) | Median | 127 | 202 | |
| IQR | 76–177 | 106–302 | ||
| n | 38 | 38 | ||
* p values were determined by Wilcoxon signed-rank test for paired samples. cHL: classical Hodgkin lymphoma; IQR: interquartile range; NK: natural killer.