Table 4.
Direct comparison of DNA methylation of BRCA1, SLFN11 and USP44 gene promoters in primary tumors and paired plasma cfDNA in advanced HGSOC (FIGO III).
| Primary Tumor | Paired Plasma cfDNA | ||
|---|---|---|---|
| BRCA1 | Unmethylated | Methylated | Total |
| Unmethylated | 31 | 4 | 35 |
| Methylated | 5 | 0 | 5 |
| Total | 36 | 4 | 40 |
| Agreement | 31/40 (77.5%), p = 0.573, k = −0.125 | ||
| SLFN11 | Unmethylated | Methylated | Total |
| Unmethylated | 32 | 1 | 33 |
| Methylated | 4 | 0 | 4 |
| Total | 36 | 1 | 37 |
| Agreement | 32/37 (86.5%), p = 0.892, k = −0.045 | ||
| USP44 | Unmethylated | Methylated | Total |
| Unmethylated | 19 | 0 | 19 |
| Methylated | 16 | 2 | 18 |
| Total | 35 | 2 | 37 |
| Agreement | 21/37 (56.8%), p = 0.230, k = 0.114 | ||