Figure 1.

Schematic view of the endosome recycling system. Retromer and retriever complexes play a fundamental role in the recycling of numerous membrane proteins, although their target proteins are distinct. Retromer and retriever complexes interact with the WASH complex and the CCC complex for endosomal recycling (see text). WASH complex has an endosomal actin-remodeling function and is required for retromer and retriever to localize to the recycling endosome, while the CCC complex is shown to interact only with retriever.