Table 1.
Patient’s clinical and histopathologic characteristics.
| Clinical and Pathological Characteristics | Total Number of Patients (allRCC), n (%) |
Subset of Patients with ccRCC, n (%) |
Subset of Patients with FU for allRCC, n (%) | Subset of Patients with FU for ccRCC, n (%) | |
|---|---|---|---|---|---|
| Total cases | 189 (100.0) | 151 (100.0) | 77 (100.0) | 57 (100.0) | |
| Histology | ccRCC | 151 (79.9) | 151(100.0) | 57 (74.0) | 57(100.0) |
| pap. RCC | 25 (13.2) | 0 (0.0) | 17 (22.1) | 0 (0.0) | |
| chrom. RCC | 3 (1.6) | 0 (0.0) | 2 (2.6) | 0 (0.0) | |
| Mixed histology * | 10 (5.3) | 0 (0.0) | 1 (1.3) | 0 (0.0) | |
| Sex | Female | 70 (37.0) | 59 (39.1) | 27 (35.1) | 22 (38.6) |
| Male | 119 (63.0) | 92 (60.9) | 50 (64.9) | 35 (61.4) | |
| Age (years) | Median | 65 | 65 | 65 | 64 |
| (min-max) | (35–91) | (35–90) | (37–91) | (37–90) | |
| Metastasis | M0 | 156 (82.5) | 123 (81.5) | 59 (76.6) | 41 (71.9) |
| M+ | 30 (15.9) | 25 (16.6) | 18 (23.4) | 16 (28.1) | |
| na | 3 (1.6) | 3 (2.0) | 0 (0.0) | 0 (0.0) | |
| Lymph node status | N0 | 168 (88.9) | 136 (90.1) | 70 (90.9) | 52 (91.2) |
| N+ | 16 (8.5) | 10 (6.6) | 7 (9.1) | 5 (8.8) | |
| na | 5 (2.6) | 5 (3.3) | 0 (0.0) | 0 (0.0) | |
| Tumor stage | pT1 | 11 (5.8) | 8 (5.3) | 8 (10.4) | 5 (8.8) |
| pT1a | 62 (32.8) | 48 (31.8) | 24 (31.2) | 15 (26.3) | |
| pT1b | 46 (24.3) | 38 (25.2) | 13 (16.9) | 9 (15.8) | |
| pT2 | 9 (4.8) | 7 (4.6) | 6 (7.8) | 5 (8.8) | |
| pT3 | 5 (2.6) | 2 (1.3) | 2 (2.6) | 1 (1.8) | |
| pT3a | 17 (9.0) | 14 (9.3) | 4 (5.2) | 4 (7.0) | |
| pT3b | 32 (16.9) | 30 (19.9) | 18 (23.4) | 17 (29.8) | |
| pT3c | 4 (2.1) | 3 (2.0) | 2 (2.6) | 1 (1.8) | |
| pT4 | 1 (0.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| na | 2 (1.1) | 1 (0.7) | 0 (0.0) | 0 (0.0) | |
| Differentiation | G1 | 36 (19.0) | 32 (21.2) | 14 (18.2) | 12 (21.1) |
| G1–2 | 20 (10.6) | 13 (8.6) | 10 (13.0) | 4 (7.0) | |
| G2 | 104 (55.0) | 82 (54.3) | 42 (54.5) | 30 (52.6) | |
| G2–3 | 10 (5.3) | 6 (4.0) | 5 (6.5) | 5 (8.8) | |
| G3 | 18 (9.5) | 17 (11.3) | 6 (7.8) | 6 (10.5) | |
| na | 1 (0.5) | 1 (0.7) | 0 (0.0) | 0 (0.0) | |
Abbreviations: ccRCC clear cell renal cell carcinoma (RCC); pap. RCC papillary RCC; chrom. RCC chromophobe RCC; FU follow-up; na not available; * mixed histology defined as fractions of different histologic subtypes of RCC (ccRCC + pap. RCC, ccRCC + chrom. RCC).