Table 3.
Bivariate logistic regression analysis of association of INA, NHLH2, and THBS4 methylation and clinicopathological characteristics.
| (a) Complete Cohort (allRCC) | ||||||
| Methylation | INA | nhlh2 | THBS4 | |||
| OR (95% CI) | p -value | OR (95% CI) | p -value | OR (95% CI) | p -value | |
| Metastasis (M0 vs. M1) | 1.05 (1.02–1.09) | 0.002 | 1.05 (1.02–1.07) | <0.001 | 1,04 (1.01–1.07) | 0.008 |
| Lymph node status (N0 vs. N1) | 1.04 (1.00–1.09) | <0.001 | 1.05 (1.02–1.09) | <0.001 | 1.04 (1.01–1.07) | 0.021 |
| Tumor stage (low vs. high T *) | 1.07 (1.04–1.10) | <0.001 | 1.06 (1.04–1.09) | <0.001 | 1.05 (1.03–1.08) | <0.001 |
| Differentiation (low vs. high G **) | 1.08 (1.04–1.12) | <0.001 | 1.06 (1.03–1.09) | <0.001 | 1.05 (1.02–1.08) | <0.001 |
| (b) ccRCC Subgroup | ||||||
| Methylation | INA | NHLH2 | THBS4 | |||
| OR (95% CI) | p -value | OR (95% CI) | p -value | OR (95% CI) | p -value | |
| Metastasis (M0 vs. M1) | 1.05 (1.01–1.09) | 0.019 | 1.03 (1.00–1.07) | 0.026 | 1.04 (1.00–1.08) | 0.048 |
| Lymph node status (N0 vs. N1) | na *** | na *** | na *** | na *** | na *** | na *** |
| Tumor stage (low vs. high T *) | 1.07 (1.03–1.10) | <0.001 | 1.05 (1.02–1.08) | <0.001 | 1.05 (1.02–1.09) | 0.001 |
| Differentiation (low vs. high G **) | 1.07 (1.03–1.12) | <0.001 | 1.05 (1.02–1.08) | <0.001 | 1.04 (1.01–1.08) | 0.021 |
Note that statistical results of covariate age are not shown as statistical significance was either not reached (ccRCC) group or low ORs of 0.95–0.96 with p-values from p = 0.02–0.05 were obtained indicating weak model effects. Abbreviations: vs. versus; na not available; OR odds ratio; 95% CI 95% confidence interval * Low defined as T1 and T2; high defined as T3 and T4; ** Low defined as G1, G2; high defined as ≥G3; *** Due to small group sizes no statistics available.