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. 2021 Dec 7;21(1):49–66. doi: 10.1021/acs.jproteome.1c00447

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© 2021 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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MALDI-TOF MSI of distinct histological structures in the human small intestine. (A) Average mass spectrum of whole tissues (Ctrl). (B) H&E staining showing annotation of histological layers, mucosa, submucosa, and muscle. See also Figure S7 for region annotations in all tissues. (C) Heatmap visualizing intensity differences for average mass spectra obtained from mucosa, submucosa, and muscle layers of the small intestine. Individual peptide images of m/z values with specific localization in (D) mucosa (m/z 886.5 ± 0.2 Da), (E) muscle (m/z 1198.7 ± 0.2 Da), (F) submucosa (m/z 840.5 ± 0.2 Da), and blood vessels (m/z 1274.6 ± 0.2 Da). All peptide images were generated from TOF-MSI data.