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. 2021 Dec 28;11(1):86. doi: 10.3390/cells11010086

Figure 8.

Figure 8

Schematic model depicting TCS-induced placental dysfunction and low birth-weight infants through PPARγ signaling pathways. TCS inhibited cell growth, angiogenesis, and migration and promoted inflammation of placenta via PPARγ-regulated genes HMOX1, ANGPTL4, VEGFA, MMP-2, MMP-9, p65, IL-6, IL-1β, and TNF-α.