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. 2021 Dec 30;11(1):109. doi: 10.3390/cells11010109

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative staining of immunohistochemical features of biopsies from patients with DM (P4), anti-Jo1-ASyS (P14), OM (P3), and controls. The upregulation of MHC class 1 on muscle fibers is ubiquitously strong in all IIM subtypes, whereas MHC class II is mainly expressed at perifascicular muscle fibers. Upregulation of MxA is the highest in DM but also present in anti-Jo1-ASyS. Inflammatory cells occur in all subtypes, mainly T-lymphocytes (CD3, CD8). B-lymphocytes (CD20) are prominent in Jo-1-ASyS. Macrophages (CD68) are prominent in all subtypes (magnification 20×). (DM = dermatomyositis; ASyS = antisynthetase syndrome; OM = overlap myositis).