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. 2021 Dec 30;11(1):109. doi: 10.3390/cells11010109

Figure 5.

Figure 5

Representative stains of immunohistochemical features of biopsies from patients with DM (P4), anti-Jo1-ASyS (P14), OM (P3) and control. In DM, complement deposits (C5b-9) on endomysial capillaries are strong at the perifascicular region but can also be present in anti-Jo1-ASyS. Strong complement deposits on myofibers are present in anti-Jo1-ASyS in a perifascicular pattern. Few complement deposits are present on scattered fibers in OM. CD31+ endomysial capillaries are reduced in DM and anti-Jo1-ASyS. Focal reduction in CD31+ vessels is also present in OM. Upregulation of vascular endothelial growth factor (VEGF) is mainly seen in DM but can also occur in anti-Jo1-ASyS and OM. Myotilin staining indicates a disorganization of sarcomeric structure. Strong perifascicular sarcomeric disruption is present in DM and less strong in anti-Jo1-ASyS. With antibodies against CD56 and MHCD, a strong regenerative capacity is seen in anti-Jo1-ASyS (magnification 20×). (DM = dermatomyositis; ASyS = antisynthetase syndrome; OM = overlap myositis).