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. 2021 Dec 30;11(1):109. doi: 10.3390/cells11010109

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MxA upregulation and tubuloreticular inclusions in muscle biopsies from patients with IIM. Strong perifascicular upregulation of interferon surrogate marker MxA in DM (P4) and anti-Jo-1 ASyS (P14) associated with tubuloreticular inclusions (TIR) in the endothelial cells of small vessels. Weak MxA upregulation on scattered myofibers with nonspecific osmiophilic inclusions in anti-PL7 ASyS (P6) and OM (P3) (magnification 20×) (DM = dermatomyositis; ASyS = antisynthetase syndrome; OM = overlap myositis).