Table 1.
Baseline characteristics of patients who had germline genetic blood tests.
| Variables | Total (n = 64) | BRCA Mutation (+) | BRCA Mutation (–) | p Value | ||
|---|---|---|---|---|---|---|
| (n = 9) | (n = 55) | |||||
| Age at diagnosis (year) | 57.5 (48.0–66.8) | 50.0 (47.0–60.0) | 59.0 (48.0–71.0) | 0.122 | ||
| Male | 24 (37.5%) | 2 (22.2%) | 22 (40.0%) | 0.464 | ||
| History of prior malignancy, n (%) | ||||||
| Yes | 19 (29.7%) | 6 (66.7%) | 13 (23.6%) | 0.016 | ||
| Breast | 6 (9.4%) | 4 (44.4%) | 2 (3.64%) | 0.014 | ||
| Family history of any malignancy, n (%) | ||||||
| Yes | 29 (45.3%) | 6 (66.7%) | 23 (41.8%) | 0.279 | ||
| Pancreas | 14 (21.9%) | 2 (22.2%) | 12 (21.8%) | 1.000 | ||
| Breast | 3 (4.7%) | 1 (11.1%) | 2 (3.6%) | 1.000 | ||
| Tobacco use (%) | ||||||
| Yes (past or current) | 16 (36.4%) | 3 (33.3%) | 19 (34.5%) | 1.000 | ||
| BMI (kg/m2) | ||||||
| ≥25.0 | 9 (14.1%) | 1 (11.1%) | 8 (14.5%) | 1.000 | ||
| Diabetes Mellitus | 18 (28.1%) | 1 (11.1%) | 17 (30.9%) | 0.425 | ||
| Hypertension | 21 (32.8%) | 2 (22.2%) | 19 (34.5%) | 0.706 | ||
| CA 19-9 (U/mL) | ||||||
| Elevated (>34.0U/mL) | 51 (79.7%) | 8 (88.9%) | 43 (78.2%) | 0.672 | ||
| Pathology | ||||||
| Well-differentiated | 2 (3.1%) | 0 (0.0%) | 2 (3.6%) | |||
| Moderately differentiated | 24 (37.5%) | 7 (77.8%) | 17 (30.9%) | |||
| Poorly differentiated | 7 (10.9%) | 2 (22.2%) | 5 (9.1%) | |||
| Clinical T stage | ||||||
| T1/2 | 25 (39.1%) | 3 (33.3%) | 22 (40.0%) | 1.000 | ||
| T3/4 | 39 (60.9%) | 6 (66.7%) | 33 (60.0%) | |||
| Clinical n stage | ||||||
| N0 | 26 (40.6%) | 5 (55.6%) | 21 (38.2%) | 0.467 | ||
| Location of primary tumor | ||||||
| Head | 32 (50.0%) | 4 (44.4%) | 28 (50.9%) | 1.000 | ||
| Metastasis site | ||||||
| Liver | 22 (34.4%) | 6 (66.7%) | 16 (29.1%) | 0.053 | ||
| Peritoneum | 13 (20.3%) | 0 (0.0%) | 13 (23.6%) | 0.185 | ||
| Distant LN | 9 (14.1%) | 1 (11.1%) | 8 (14.5%) | 1.000 | ||
| Number of metastasis site | ||||||
| 0 site | 33 (51.6%) | 3 (33.3%) | 30 (54.5%) | 0.296 | ||
| 1 or more sites | 31 (48.4%) | 6 (66.7%) | 25 (45.5%) |
Data are in n (%) or median (IQR). BRCA: breast cancer susceptibility gene; BMI: body mass index; CA: carbohydrate antigen; LN: lymph node; IQR: interquartile range.