Figure A1.

Comparison between administration protocols obtained with different values of the parameter $k_{AC}$. The dynamics refer to the ipilimumab mono-therapy as result of the optimization problem OP2, with ${\Delta }_t=3$ weeks. Blue lines represent the model outcomes with the estimate value of $k_{AC}$ (the same presented in Figure 6, blue line), while orange lines represent the one with $\frac{k_{AC}}{2}$. The ipilimumab threshold has been highlighted with a black dotted line.