Figure A2.

Comparison between administration protocols obtained with different values of the parameter $k_{AC}$. The dynamics refer to the ipilimumab and sipuleucel-T combination therapy as result of the optimization problem OP2, with ${\Delta }_t=1$ week. Blue lines represent the model outcomes with the estimate value of $k_{AC}$ (the same presented in Figure 5, orange line), while orange lines represent the one with $\frac{k_{AC}}{2}$. The ipilimumab threshold has been highlighted with a black dotted line.