Figure 4.

Assessment of the effects of ATM, ATR and DNA-PKcs inhibitors on the activation of G₁ checkpoint in irradiated G₀ cells of SD 82-6 hTert cell cultures. (a) As in Figure 1b for cells exposed to 0 or 1 Gy in the presence of ATMi as indicated. (b) As in (a) for cells exposed to CHK2 inhibitors as indicated. (c) As in (a) for cells exposed to CHK1 inhibitors as indicated. (d) As in (a) for unirradiated cells treated with DNA-PKcsi in the presence or absence of ATMi and or ATRi. (e) As in (d) for cells exposed to 1 Gy of X-rays. (f) As in panel (a), for cells exposed to 0 or 10 Gy in the presence or absence of a CHK2 inhibitor as indicated. Broken lines show results from (b) without data point to avoid congestion. Plotted is the mean and SE from three independent experiments. See also Table S3 for more information.