Table 2.
Serum and urine variables (mean ± standard deviation) of nondiabetic rats (NDR), diabetic control rats (DR), and DR treated with hydroxytyrosol (HT) 5 mg/kg/day p.o. (HT-5), 3′,4′-dihidroxifenilglicol (DHPG) 0.5 or 1 mg/kg/day p.o. (DHPG-0.5, DHPG-1), or their association. n = 10 rats per group.
| Variable | NDR | DR | HT-5 | DHPG-0.5 | DHPG-1 | HT-5 + DHPG-0.5 | HT-5 + DHPG-1 |
|---|---|---|---|---|---|---|---|
| Blood glucose (mg/dL) | 95.1 ± 5.3 | 456 ± 10.0 (+) | 460 ± 9.7 | 384 ± 32.5 | 424 ± 36.7 | 329 ± 39.8 | 420 ± 10.8 |
| Total cholesterol (mg/dL) | 57.5 ± 7.4 | 78.7 ± 4.7 | 68.3 ± 2.5 | 75.2 ± 7.5 | 71.0 ± 9.1 | 70.7 ± 6.7 | 72.5 ± 4.7 |
| LDL cholesterol (mg/dL) | 23.2 ± 5.4 | 33.5 ± 5.8 | 30.1 ± 7.8 | 34.0 ± 6.8 | 29.2 ± 6.1 | 28.2 ± 7.1 | 27.7 ± 4.1 |
| HDL cholesterol (mg/dL) | 18.5 ± 2.4 | 18.4 ± 4.8 | 28.0 ± 8.1 (*) | 25.5 ±5.4 | 27.5 ± 4.4 | 24.5 ± 4.1 | 25.2 ± 2.8 |
| Triglycerides (mg/dL) | 67.5± 7.7 | 105 ± 13.7 (+) | 102 ± 6.6 | 108 ± 6.5 | 109 ± 13.5 | 85.5 ± 7.8 (*,a) | 110 ± 7.4 (*) |
+p < 0.05 with respect to NDR; * p < 0.05 with respect to DR; a p < 0.05 with respect to HT-5, DHPG-0.5 and DHPG-1.