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AG490 reduced endothelial permeability increased by IL-6 in bEnd.3 cells: (A) TEER, (B) permeability to dextran-FITC in bEnd.3 cells pretreated with vehicle, AG490 (50 µM), or MG132 (5 µM) for 30 min before incubation with recombinant IL-6 (0 and 50 ng/mL) for an additional 24 h; (C) Western blot of bEnd.3 extracted proteins with ZO-1 antibody and the quantitative results. * p < 0.05 vs. untreated control; # p < 0.05 vs. IL-6 control, n = 4.
