Table 1.
Characteristics of patients with a keratinocyte skin cancer associated with paraneoplastic syndromes.
| Ref a | Tumor | PNS b | Age/Sex | Localization | History | Recurrence/Metastases c | Timing of PNS d | Tumor/PNS Treatment | Resolution of PNS |
|---|---|---|---|---|---|---|---|---|---|
| [9] | SCC | Bazex Syndrome | 69/M | Axilla (metastasis) | SCC ipsilateral forearm | No/Yes | Before | Chemothe-rapy | Yes |
| [10] | SCC | Inflammatory arthralgias | 52/M | Skin (area N/A) | N/A | No/No | After | Surgery | Yes |
| [11] | SCC | Neuropathy | 50/M | Perineal | Hidradenitis suppurativa | No/No | Before | Surgery | Yes |
| [12] | SCC | Hypercalcemia | 67/M | Chest wall | Semi-comatose patient | No/No | Simultane-ously | Patient refused therapy | No |
| [13] | SCC | Hypercalcemia, leukocytosis | 58/M | Sole | Scar (accident) | No/Yes | After | Surgery, chemothe-rapy, radiation | Yes |
| [14] | SCC | Hypercalcemia | 82/M | Finger | Excision 2 years ago | Yes/Yes | After | Surgery, chemothe-rapy, radiation | No (patient died) |
| [15] | SCC | Bazex Syndrome | 54/M | Leg | Old scar | No/No | After | Surgery | Yes |
| [16] | SCC | Hypercalcemia | 38/M | Axilla | SCC on arm (burn scar area) | Yes/Yes | After | Surgery | Yes |
| [17] | SCC | Hypercalcemia, leukocytosis | 50/M | Sacral | Hidradenitis suppurativa | No/Yes | Simultane-ously | Chemo-therapy | No |
| [17] | SCC | Hypercalcemia | 60/M | Hand | N/A | No/Yes | After | Chem-otherapy | No |
| [18] | SCC | Hypercalcemia, leukocytosis | 20/M | Foot | Recessive dystrophic EB | Yes/Yes | Simultane-ously | Surgery, zolendro-nate | Yes |
| [19] | SCC | Hypercalcemia | 74/M | Back | Porokerato-sis Mibelli | Yes/Yes | After | Surgery | Yes |
| [20] | SCC | Hypercalcemia | 65/M | Buttock | Hidradenitis Suppurativa | Yes/Yes | After | Surgery, radiotherapy | Yes |
| [21] | SCC | Hypercalcemia | 72/M | Leg | Chronic venous ulcer | No/No | Simultane-ously | Surgery | No |
| [22] | SCC | Hypercalcemia | 45/M | Sacral | N/A | No/Yes | Simultane-ously | Cetuximab | No |
| [23] | SCC | Hypercalcemia | 59/M | Scapular area | ‘Pyoderma chronica’ | Yes/No | After | Chemo-therapy, radiation | Yes |
| [24] | SCC | Hypercalcemia | 65/F | Back | Lethargy | No/Yes | Simultane-ously | Chemo-therapy | Yes |
| [25] | SCC | Hypercalcemia | 80/F | Leg | Thrombo-phlebitis | No/No | Simultane-ously | Surgery | No (patient died) |
| [26] | SCC | Hypercalcemia | 17/M | Leg | Epidermo-lysis bullosa | Yes/Unknown | After | Denosumab | Yes |
| [27] | SCC | Hypercalcemia | 38/M | Back | Burn scar | No/No | Simultane-ously | Surgery | Yes |
| [28] | SCC | Hypercalcemia | 68/F | Arm | N/A | No/No | Simultane-ously | Surgery | Yes |
| [29] | BCC | Antiphospho-lipid syndrome | 64/F | Face | Chronic heart failure | No/No | After | Surgery | Yes |
| [30] | BCC | Pure red cell aplasia | 65/M | Shoulder | Hyper-tension | Yes/Yes | After | Surgery, radiatio,-chemo-therapy | No |
| [31] | TRC | Hypercalcemia | 42/M | Scalp | Burn scar | No/No | Simultane-ously | Surgery | Yes |
| [32] | PLM | Hypercalcemia | 32/M | Neck | N/A | No/No | Simultane-ously | Surgery | Yes |
| [33] | SCC | Pure Red Cell Aplasia | 80/M | Ear | Benign Prostate Hypertrophy | No/Unknown | Before | Surgery | No |
| [34] | SCC | Hypercalcemia leucocytosis | 5/F | Face | Xeroderma pigmento-sum | No/No | Simultane-ously | Chemo-therapy | Yes |
| [35] | SCC | Hypercalcemia | 83/M | Retro-Ear | N/A | No/Yes | Simultane-ously | Radio-therapy | Yes |
| [36] | SCC | Hypercalcemia | 35/M | Buttock | Hidradenitis suppurativa | No/No | Simultane-ously | Chemo-therapy | N/A |
| [37] | SCC | Hypercalcemia | 81/M | Chest wall | BCC | No/No | Simultane-ously | Surgery | Yes |
| [38] | SCC | Hypercalcemia | 50/M | Hip | Hidradenitis suppurativa | No/Yes | Simultane-ously | Surgery | Yes |
| [39] | SCC | Hypercalcemia, leukocytosis | 45/M | Thigh | Burn scar | Yes/Yes | Simultane-ously | Chemo-therapy | Yes |
| [40] | SCC | Hypercalcemia | 62/M | Groin | Psoriasis/chronic arsenic ingestion | No/No | After | Surgery | N/A |
| [41] | BCC | Anaemia | 50/M | Chest wall | N/A | N/A/No | After | Surgery | Yes |
| [42] | BCC | Anaemia | 76/F | Face | N/A | N/A | Simultane-ously | Radio-therapy | N/A |
| [43] | SCC | Hypercalcemia | 53/M | Back | N/A | N/A/Yes | Simultane-ously | Chemo-therapy | No (patient died) |
| [44] | SCC | Hypercalcemia | 68/M | Buttocks | Hidradenitis suppurativa | Yes/N/A | After | Chemo-therapy | No (patient died) |
| [45] | SCC | Hypercalcemia | 63/M | Buttocks | Hidradenitis suppurativa | N/A | Simultane-ously | Surgery | No (patient died) |
| [46] | SCC | Hypercalcemia | 51/M | Buttocks | Hidradenitis suppurativa | Yes/No | After | None specific | No (patient died) |
| [48] | SCC | Hypercalcemia | 28/F | Ischial tuberosity | Paraplegia/-chronic decubitus ulcer | No/Yes | Simultane-ously | Zolendronic acid | Yes |
| [49] | SCC | Hypercalcemia | 58/M | Leg | Lymph-edema | No/No | Simultane-ously | Surgery | Yes |
The background color highlights the data that refer to one case. a Ref: References list number. b Abreviations. F: female; KSC: Keratinocyte Skin Cancer; M: male; N/A: information not available; PLM: pilomatricoma; PNS:paraneoplastic syndrome; SCC: cutaneous Squamous Cell Carcinoma; TRC: trichilemmal carcinoma. c Recurrence: local relapse; metastasis: distant relapse. d Timing of PNS. before: PNS diagnosis precedes tumor diagnosis; simultaneous: PNS present at the time of tumor diagnosis; after: PNS diagnosis after tumor diagnosis.