Table 4.
Age of patients (Median [Range]) at the time of diagnosis of a keratinocyte skin cancer associated paraneoplastic syndrome, stratified according to patients’ gender.
| Factor | Total (N = 41) | Male (N = 34) | Female (N = 7) | |
|---|---|---|---|---|
| Tumor a | BCC (N = 4) | 64.5 [50–76] | 57.5 [50–64] | 70.0 [64–76] |
| SCC (N = 35) | 58.0 [5–83] | 58.0 [17–83] | 66.5 [05–80] | |
| Other b (N = 2) | 37.0 [32–42] * | 37.0 [32–42] * | - | |
| PNS | HHM all (N = 32) | 51.0 [5–83] | 58.0 [17–83] | 65.0 [5–80] |
| HHM without Leukocytosis (N = 27) | 60.0 [17–83] | 59.0 [17–83] | 66.5 [5–80] | |
| HHM with Leukocytosis (N = 5) | 45.0 [5–58] | 47.5 [20–58] | 5 * | |
| Other than HHM (N = 9) | 64.0 [50–80] | 54.0 [50–80] | 64 * | |
| Anemia (N = 4) | 70.5 [50–80] | 65.0 [50–80] | 76 * | |
| Bazex syndrome (N = 2) | 61.5 [54–69] * | 61.5 [54–69] * | - | |
| Other c (N = 3) | 52.0 [50–64] | 51.0 [50–52] | 64 * | |
| Localization d | Head/Neck (N = 7) | 64.0 [5–83] | 61.0 [32–83] | 64.0 [5–76] |
| Trunk (N = 20) | 56.0 [28–81] | 59.0 [28–81] | 28 * | |
| Extremities (N = 13) | 58.0 [17–82] | 56.0 [17–82] | 68.0 [65–68] | |
| N/A (N = 1) | 52 * | 52 * | - | |
| Predilection e | No (N = 9) | 74.5 [64–82] | 67.0 [65–82] | 65.0 [64–80] |
| Yes (N = 23) | 50.0 [5–74] | 52.5 [17–74] | 5 * | |
| N/A (N = 9) | 62.5 [32–83] | 52.0 [32–83] | 72.0 [68–76] | |
| Genodermatosis (N = 4) | 18.5 [5–74] | 20.0 [17–74] | 5 * | |
| Acquired f (N = 19) | 51.0 [28–72] | 58.0 [35–72] | 28 * | |
| Scar/ulcus (N = 9) | 45.0 [28–72] | 52.5 [38–72] | 28 * | |
| Hidradenitis suppurativa (N = 8) | 50.5 [35–68] | 50.0 [35–68] | - | |
| Other g (N = 2) | 60.0 [58–62] * | 69.0 [62–74] * | - | |
| Resolution h | No (N = 13) | 65.0 [45–82] | 63.0 [45–82] | 72.5 [65–80] |
| Yes (N = 25) | 52.0 [5–83] | 52.0 [17–83] | 46.0 [5–68] | |
| N/A (N = 3) | 62.5 [35–76] | 48.5 [35–62] * | 76 * |
The different colors separate rows referring to the different factor. Italics indicate data referring to subcategories of factors. a Abbreviations. BCC: basal cell carcinoma, SCC: cutaneous squamous cell carcinoma, HHM: humoral hypercalcemia of malignancy, PNS: paraneoplastic syndrome. b Trichilemmal carcinoma, pilomatrixoma. c Inflammatory arthralgias, neuropathy, antiphospholipid syndrome. d Localization: localization of the primary neoplasm. e Predilection: presence of a condition that predisposes to skin cancer development. f Acquired: acquired predilection. g Chronic arsenic intoxication, lymphedema. h Resolution: resolution of paraneoplastic syndrome after skin cancer treatment. * For <3 cases single values instead of ‘range’ are displayed.