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. 2021 Dec 23;14(1):59. doi: 10.3390/cancers14010059

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Spontaneous physical activity induces an immune anti-inflammatory microenvironment in the tumours. (A) Tumour lymphocytes T-helper infiltrate, results are in cells per mg of tumour. (n = 5 mice tumour phenotyping analysis/group) (B) Quantity of IL-5 in tumour, results are in pg/mg of tissue. (C) Quantity of IL-6 in tumour, results are in pg/mg of tissue. (D) Quantity of IL-4 in tumour, results are in pg/mg of tissue. (E) Quantity of IFN-γ in tumour, results are in pg/mg of tissue. (F) Ratio of IFN-γ/IL-4 in tumour, results are a ratio of IFN-γ (in pg/mg of tissue) divided by IL-4 in (in pg/mg of tissue). Cytokine determination is performed on 5 mice tumour samples/group. Data are mean ± SEM. Data were analysed by Mann–Whitney t-test. Representative data are shown: * p < 0.05, SE vs. EE.