Figure 3.

Treatment efficacy of various treatment modalities on immunocompetent and immunodeficient mouse models. (A) Clonogenic assay utilized to evaluate the in vitro response of B16-F10 after different doses of radiation in the following two treatment modalities: CRT and MRT. (B,C,J) Kaplan–Meier curves demonstrate the fraction of mice that survived at different time-points after tumor cell inoculation, the p-values calculated by log-rank test and adjusted using FDR. (D–I,K–M) Tumor size at different time-points after tumor inoculation in the different treatment groups, in immunocompetent, Rag^−/− and CD8-depleted mouse models. (F) One mouse in MRT group survived the primary challenge. MRT: microplanar radiotherapy; CRT: conventional radiotherapy; Rag^−/−: model is homozygous for the Rag^1tm1Mom mutation, and lacks mature T and B cells; aCD8: injected with anti-CD8.