Figure 1.
Gene expression profiles of Tcea3 KD mESCs. (A) Scatter plots of cDNA microarray analysis of Tcea3 KD mESCs (R 2 = correlation coefficients) showing that 117 genes are activated and 94 genes are suppressed in Tcea3 KD mESCs. (B) Panther classification of 211 genes showed that major regulators of vasculogenesis are activated in Tcea3 KD mESCs. (C) Scatter plots of cDNA microarray analysis of differentiating Tcea3 KD mESCs (R 2 = correlation coefficients) showing that 105 genes are activated and 170 genes are suppressed in Tcea3 KD mESCs. Differentiation of mESCs was induced by culturing in medium lacking LIF for 3 days. (D) Panther classification of 275 genes showed that 18 of 21 ectoderm lineage marker genes were suppressed, whereas 7 of 9 mesoderm lineage marker genes were activated.