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The four types of protein inhibitors in the treatment of hematological malignancies and their mechanisms of action. BCL-2: B-cell leukemia/lymphoma-2. Bim: BCL-2-like protein 11. BAX: BCL-2-associated X protein. BAK: BCL-2 antagonist/killer 1. MOMP: mitochondrial outer membrane permeabilization. XPO1: exportin-1. TSP: tumor suppressor protein. Ub: ubiquitin. ADP: adenosine diphosphate. Created with BioRender.com.
