Table 2.
Somatic mutations present in FaDu Resistant compared with FaDu Parental cell line.
| Chromosome | cDNA | Protein | Consequence | Gene | Driver Status |
|---|---|---|---|---|---|
| chr 1 | c.2492A>T | p.N831I | Missense | EPHA2 | Tumor Driver |
| chr 2 | c.2074G>T | p.G692W | Missense | ALK | Tumor Driver |
| chr 6 | c.6341A>G | p.Y2114C | Missense | ROS1 | Tumor Driver |
| chr 6 | c.3391A>T | p.K1131* | Nonsense | ZNF292 | Tumor Driver |
| chr 8 | c.1648delT | p.S550Qfs*12 | Frameshift | UBR5 | Tumor Driver |
| chr 9 | c.3127_3129delAGC | p.S1043delS | In Frame Deletion | TSC1 | Tumor Driver |
| chr 9 | c.740delC | p.P247Qfs*30 | Frameshift | NOTCH1 | Tumor Driver |
| chr 9 | c.250_252delGAA | p.E84delE | In Frame Deletion | XPA | Tumor Driver |
| chr 13 | c.3273dupG | p.K1092Efs*233 | Frameshift | IRS2 | Tumor Driver |
| chr 14 | c.928delG | p.E310Kfs*68 | Frameshift | ARID4A | Tumor Driver |
| chr 15 | c.3416delG | p.G1139Efs*25 | Frameshift | FANCI | Tumor Driver |
| chr 16 | c.1183delC | p.H395Tfs*78 | Frameshift | TRAF7 | Tumor Driver |
| chr 17 | c.1420_1422delCAT | p.H474delH | In Frame Deletion | AXIN2 | Tumor Driver |
| chr 19 | c.209A>T | p.N70I | Missense | ARHGAP35 | Tumor Driver |
| chr 21 | c.146delC | p.P49Qfs*4 | Frameshift | RUNX1 | Tumor Driver |
* Stop codon sequencing.