Table 4.

Molecular characteristics of hypodiploid <40 chromosomes B-ALL (Adapted from Holmfelt et al., 2013 [30]).

Genes	Cellular Pathway	Near-Haploid B-ALL			Low-Hypodiploid B-ALL
		Mutation	Focal Deletion	Focal DEL + Mut	Mutation	Focal Deletion	Focal DEL + Mut
NF1	RTK/RAS pathway	11/68 (16%)	16/68 (24%)	3/68 (4%)	0	2/34 (6%)	0
KRAS		2/68 (3%)	0	0	0	0	0
NRAS		10/68 (15%)	0	0	0	0	0
PTPN11		1/68 (1%)	0	0	0	0	0
FLT3		6/68 (9%)	0	0	0	0	0
CRLF2		0	2/68 (3%) *	0	0	0	0
MAPK1		1/68 (1%)	0	0	0	0	0
GAB2		0	2/68 (3%)	0	0	1/34 (3%)	0
EPHA7		0	2/68 (3%)	0	0	0	0
RASA2		0	2/68 (3%)	0	0	0	0
IKZF1	B-cell development	0	3/68 (4%)	0	0	1/34 (3%)	0
IKZF2		1/68 (1%)	0	0	0	18/34 (53%)	0
IKZF3		1/68 (1%)	8/68 (12%)	0	0	1/34 (3%)	0
PAX5		1/68 (1%)	4/68 (6%)	0	0	2/34 (6%)	0
EBF1		0	0	0	0	0	0
VPREB1		0	3/68 (4%)	0	0	2/34 (6%)	0
CDKN2A/B	Cell cycle and apoptosis	0	15/68 (22%)	0	0	8/34 (24%)	0
TP53		2/68 (3%)	0	0	31/34 (91%)	0	0
RB1		2/68 (3%)	3/68 (4%)	1/68 (1%)	5/34 (15%)	8/34 (24%)	0
ETV6	Hematopoiesis	1/68 (1%)	3/68 (4%)	1/68 (1%)	0	0	0
Histone cluster (6p22)	Histone-related	0	13/68 (19%)	0	0	1/34 (3%)	0
ARID1B		0	2/68 (3%)	0	0	0	0
PAG1	BCR signalling	1/68 (1%)	6/68 (9%)	0	0	1/34 (3%)	0
ARPP21	Calmodulin signalling	0	1/68 (1%)	0	0	0	0
SLX4IP (C20orf194)	Telomere length maintenance	0	2/68 (3%)	0	0	0	0
CUL5	Ubiquitin pathway	0	2/68 (3%)	0	0	0	0
FAM53B	Wnt signalling	0	2/68 (3%)	0	0	0	0
PDS5B (APRIN)	Cohesin complex	0	2/68 (3%)	0	0	0	0
ANKRD11	Cell adhesion	0	0	0	0	2/34 (6%)	0
DMD		0	0	0	0	1/34 (3%)	0

* one patient encoding P2RY8-CRLF2.