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. 2022 Jan 4;11(1):160. doi: 10.3390/cells11010160

Figure 3.

Figure 3

A general outline of the functioning of the Hippo pathway. Diagram presents central axis of pathway consisting of ‘core kinases’ MST1/2, LATS1/2, their up-stream modulators: Merlin/NF2, Kibra/WWC1/2 and effector part of the pathway—YAP (Yes-associated protein encoded by YAP1). What is worth mentioning is active ‘core kinases’ phosphorylate YAP resulting in its cytoplasmic sequestration and down-regulation of the pathway activity. A detailed description of the pathway functioning is in the text of the article. MST1/2 (mammalian sterile 20-like kinases), LATS (large tumor suppressor kinases), Vgll1-4 (vestigial-like, Vito, Tondu), Tead1-4 (TEA/ATTS domain/TEF/scalloped), Merlin/NF2 (neurofibromatosis type 2), WW45/Sav1 (adaptor proteins Salvador homologue1), MOBKL1A (Mps-one binder kinase activator 1), TAOK1, thousand-and-one amino acids kinase 1, Amot (angiomotin). FOXO3a (Forkhead box O3).