Table 2.

List of reported plant extracts with anti-tuberculosis activities against different M. tuberculosis isolates.

Plant (Bioactive Compound)	Extract	Mtb	MIC	References
Lantana hispida (-acetoxy-22-(2′-methyl-2Z-butenyloxy)-12-oleanen-28-oic acid, hydroxy-22β-(2′-methyl-2Z-butenoyloxy)-12-oleanen-28-oic acid and oleanolic acid)	Hexane extract	Mycobacterium tuberculosis strain H37Rv	50, 50 and 25 μg/mL respectively	[61]
Taxus baccata	Chloroform extract of heartwood and ethanolic extract of leaves	M. tuberculosis strain H37Ra	200 μg/mL	[62]
Adhatoda vasica (2-acetyl benzylamine and vasicine acetate)	Hexane extract	Mtb	200 and 50 μg/mL, respectively	[63]
Terminalia phanerophlebia	Ethanolic extract of leaves	M. tuberculosis H37Ra	390 μg/mL	[64]
Opuntia ficus-indica	Methanolic extract of the plant (summer season)	M. tuberculosis strain H37Rv (ATCC 27294)	50 μg/mL	[65]
Angiopteris evecta	Methanolic extract of leaves	M. tuberculosis H37Rv	400 μg/mL	[66]
Costus speciosus, Piper sarmentosum, Pluchea indica, Pluchea indica, and Tabernaemontana coronaria	Methanolic extract		800 μg/mL
Zanthoxylum capense (Decarine)	Methanolic extract of roots	M. tuberculosis H37Ra (ATCC 25177) and M. tuberculosis H37Rv (ATCC 27294)	1.6 μg/mL	[67]
Helichrysum devium	Methanolic extract	M. tuberculosis H37Rv	50 μg/mL	[68]
H. melaleucum			100 μg/mL
H. obconicum			200 μg/mL
Artemisia capillaris (hydroquinone and ursolic acid)	Methanolic extract	M. tuberculosis strain H37Rv and two clinical isolates (resistant and sensitive)	12.5 μg/mL against sensitive strains of Mtb while a range of 12.5 to 25 μg/mL against the resistant strains	[69]
Curtisia dentata	Methanolic extract of leaves	M. tuberculosis H37RV (ATCC 27294)	22.2 μg/mL	[70]
Curtisia dentata (ursolic acid acetate)	Ethanolic extract		3.4 µg/mL
Aristolochia taliscana (Licarin A)	Hexane extract	M. tuberculosis strains: H37Rv, four mono-resistant H37Rv variants and 12 clinical MDR isolates	3.12–12.5 μg/mL	[71]
Excoecaria agallocha	Methanolic extract	M. tuberculosis H37Rv and two clinical isolates of Mtb	88.95% of antimycobacterial activity against M. tuberculosis H37Rv while 70.02% and 82.54% for other two isolates at 500 µg/mL concentration	[72]
Lantana camara	Chloroform and methanol extracts of leaves	Mycobacterium tuberculosis H37Rv, rifampicin-resistant TMC-331 and a non-resistant wildstrain (28–25271	5.0 mg/mL to 50.0 mg/mL	[73]
Solanum torvum Sw.	hydro-ethanolic extracts	Mycobacterium tuberculosis H37Ra	156.3 µg/mL	[74]
Alpinia galanga L. Willd.	Acetone, aqueous and ethanolic extracts of rhizomes	Mycobacterium tuberculosis (M.tb) H37Rv	50–100 μg/mL	[75]
Lantana camara L., Euphorbia hirta L., Mukia maderaspatana (L.) M. Roem, and Abutilon indicum L.	Methanolic crude extracts	Mycobacterium tuberculosis (Mtb) and Mtb H37Rv	400–1600 μg/mL	[76]
Artemisia annua	Dichloromethane extracts	Mycobacterium tuberculosis (Mtb), Mycobacterium abscessus	37.5 µg/mL	[77]
and A. afra			<1.3 µg/mL
Zingiber officinale	Hydroethanolic extract of rhizomes	M. tuberculosis H37Rv (ATCC 27294)	1250 μg/mL	[78]
Vitellaria paradoxa	Hydroethanolic extract of bark		78.13 μg/mL
Alstonia boonei			156 μg/mL
Musa spp. AAB, cv. ‘‘Manzano’’	n-hexane extract and ethyl acetate extract	Mycobacterium tuberculosis	12.5 and 6.25 l g/mL	[79]
Trixis angustifolia	Hexane extract	Mycobacterium tuberculosis H37Rv	12.5- 25.0 μg/mL	[80]
Acacia farnesiana	hexane, chloroform and methanolic extracts	Mycobacterium tuberculosis H37Rv and G122	100–200 µg/mL	[81]
Pterolobium stellatum (Forssk)	Chloroform extracts	M. tuberculosis strain H37RV	0.312 mg/mL	[82]
Persea americana Mill L.			2.5 mg/mL
Otostegia integrifolia Benth L.			0.312 mg/mL
Aegle marmelos L, Glycyrrhiza glabra L, Lawsonia inermis L, Piper nigrum L, and Syzygium aromaticum L.	Methanolic extract	M. tuberculosis strain H37RV	0.8 to 100 μg/mL	[83]
Boswellia serrata Roxb. ex, Datura stramonium L and Lavandula stoechas L.	Ethanolic extracts	M. tuberculosis strain H37RV	125 to 250 μg/mL	[84]
Pinus merkusii	Ethanolic extract	Mycobacterium tuberculosis H37Rv	1000 µg/mL	[85]
Dendrophthoe falcata L.	Ethanol water and methanol: water extracts	Mycobacterium tuberculosis (H37Rv strain)	6.25 μg/mL	[86]
Tridax procumbens L.			0.8 μg/mL
Triclisia gilletii	Methanol extract	Mycobacterium tuberculosis	3.90 to 62.5 μg/mL	[87]
Combretum hereroense	Hexane, dichloromethane, methanol, and acetone	M. smegmatis (ATCC 1441), M. tuberculosis (ATCC H37Rv)	1.6 mg/mL and 1.3 mg/mL	[88]
Citrus lemon			0.3 mg/mL
Apodytes dimidiata			1.3 mg/mL
Cinnamomum verum	Aqueous & methanolic extracts	Mycobacterium tuberculosis H37Rv	10 mcg/mL	[89]
Solanum surattense
Costus speciosus, Cymbopogon citratus, and Tabernaemontana coronaria	Methanol extracts	Mycobacterium tuberculosis H37Rv	100–200 μg/mL	[90]
Croton tonkinensis	Methylene chloride extracts	M. tuberculosis H37Ra, H37Rv	6.25 and 12.5 µg/mL	[91]
Melia azedarach L. and Lobelia chinensis Lour.	Methanol and n-hexane extract	M. tuberculosis	100 µg/mL	[92]