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In vivo biosafety of the active flavonoid ingredients isolated from the two Apocynum spp. (A), Blood routine assay of red blood cell (RBC), hemoglobin (HGB), Platelet (PLT) and white blood cells (WBC). (B), Histopathological examination of major organs including the heart, liver, spleen, lungs, and kidneys at day 14 after different treatments. (C), H&E staining of the heart, liver, spleen, lung, and kidney at day 12 after with different treatments.
