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. 2022 Jan 5;11(1):173. doi: 10.3390/cells11010173

Figure 7.

Figure 7

The variants of DS can induce rapid alterations in the mitochondrial transmembrane potential (∆Ψm) of the luminal breast cancer cells in a manner that is dependent on the structure of these molecules and cell type. (A,C) The dynamics of ∆Ψm in the BT-483 (A) and T-47D (C) cells that were cultured in the presence of NF and PM or DF and PM, respectively, for the indicated time periods. ∆Ψm was estimated as a ratio of red-to-green fluorescence, which is dependent on the mitochondrial membrane status-mediated polymerization of JC-1. The measurement of fluorescence was conducted for the bodies of all of the cells that were present in at least ten non-overlapping fields from each of two independent experiments. The results are expressed as the mean ±SEM. *—difference statistically significant (p ≤ 0.05) versus the control. (B,D) Representative images that show the most prominent effects of the tested DS variants on ∆Ψm in the cultures of BT-483 (B) and T-47D (D) cells. The images were taken at a magnification of ×400.