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. 2021 Dec 28;12:788107. doi: 10.3389/fendo.2021.788107

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Copyright © 2021 Joad, Ballato, Deepika, Gregori, Fleires-Gutierrez, Colleluori, Aguirre, Chen, Russo, Fuenmayor Lopez, Qualls, Villareal and Armamento-Villareal

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Threshold model of Osteocalcin versus Hemoglobin A1c by nonlinear regression (multiple correlation r=0.31, p<0.001) with least squares fitted (optimal) threshold A1c=7.0. Model Osteocalcin values= 6.57 for A1c< 7.0 and 3.86 for A1c ≥ 7.0. The threshold model is statistically significant compared to a null hypothesis of no threshold (P<0.001). (B) Threshold model of C-telopeptide versus Hemoglobin A1c by nonlinear regression (multiple correlation r=0.31, p<0.001 with least squares fitted (optimal) threshold A1c=7.0. Model C-telopeptide values= 0.311 for A1c < 7.0 and 0.182 for A1c ≥ 7.0. The threshold model is statistically significant compared to a null hypothesis of no threshold (p<0.001).