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[Preprint]. 2022 Jan 26:2022.01.03.474779. Originally published 2022 Jan 4. [Version 3] doi: 10.1101/2022.01.03.474779

Scheme 1. Synthesis of 3-Cyano-pyrazolo[1,5-a]pyrimidines 8–33.a.

Scheme 1.

a Reagents and conditions: (A) BINAP, Pd(OAc)2, t-BuOLi, 1,4-dioxane, microwave irradiation. R1 defined in Table 2. (B) Xantphos, Pd(OAc)2, Cs2CO3, 1,4-dioxane, microwave irradiation, 130 °C 130 °C. R2 defined in Table 3.