Figure 3.

Candidate AKAP-like helix in the LRRK2 ROC domain. The sequence of the ROC domain is presented with alpha helices identified from sequence analysis highlighted in green. A candidate amphipathic helix was identified within the ROC domain of LRRK2 and is highlighted by the black lines leading to the inset image of the helical wheel. This helix contains the clinically relevant residue R1441 (circled in red). In the legend the “+” indicates resides belonging to a hydrophobic face when a 3–11 helix is generated. The “*” indicates residues belonging to the hydrophobic face when an alpha helix is modeled. The “#” identifies residues that belong to the hydrophobic face when either a 3–11 or alpha helix is generated.