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. 2021 Dec 21;14(1):5. doi: 10.3390/cancers14010005

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a–c) Uptake studies of the targeted (TpHResMic) and no targeted micelles (pHResMic) on 2D model of PDAC cells. The histogram plots report the mean fluorescence values obtained after incubation for 1 h of PDAC cells with BDP@TpHResMic and BDP@pHResMic at pH 6.8 medium and at 37 °C or 4 °C, and refer to three independent experiments. (d) The histogram plots report the mean ± SD of the fluorescence values obtained in the competition study of the targeted BDP@TpHResMic, with AE105 peptide in AsPC−1 cell line. (** p < 0.01, *** p < 0.001).