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. 2021 Dec 25;14(1):98. doi: 10.3390/cancers14010098

Figure 1.

Figure 1

Description of the semi-mechanistic model. AMT: unknown dose amount; K: the treatment kinetic rate constant (days−1); KPROD: the zero order CA-125 tumor production rate (IU mL−1 days−1); BETA: tumor growth rate (days−1); KELIM: the first-order CA-125 elimination rate (days−1); fEFFECT: production inhibition; C1: central compartment receiving chemotherapy dosing; and C2: transit compartment to describe the treatment lag-time effect. CA0 corresponds to the estimated baseline CA-125 and “t” the time (Adjusted from You et al., Gynecol Oncol 2013 [21]).