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Key differences in antigen-binding domains between scFv-based, natural receptor-based, and ligand-based CAR designs. (A) scFv-based CARs; (B) natural receptor-based CARs may contain the transmembrane and/or costimulatory domains from the natural receptor itself or other sources, like CD28 or 4-1BB; (C) ligand-based CARs. Costim; Costimulation. scFv; single-chain variable fragment. TM; transmembrane. VH; Variable heavy chain. VL; Variable light chain. Created with BioRender.com.
