. 2021 Dec 23;14(1):65. doi: 10.3390/cancers14010065

Table 2.

Diagnostic performance of fecal miRNA panels for CRC.

First Author (Year) [Ref.]	Cases vs. Controls		Panel	No. of miRNA	AUC	p-Value	SEN (%)	SPE (%)
First Author (Year) [Ref.]	Study Group	N	Panel	No. of miRNA	AUC	p-Value	SEN (%)	SPE (%)
Wu, C.W., et al. (2012) [23]	CRC Cn	88 101	Panel A	2	-	-	82	57
Yau, T.O., et al. (2014) [27]	CRC Cn	198 198	Panel B	2	0.75	-	66	75
			Panel C	2	0.78	-	66	80
			Panel D	2	0.75	-	66	75
			Panel E	3	0.79	-	71	74
Yau, T.O., et al. (2016) [29]	CRC Cn	198 198	Panel F	2	0.79	-	79	65
Yau, T.O., et al. (2016) [29]	CRC Cn	198 198	Panel G	2	0.77	-	57	84
Chang, P.Y., et al. (2016) [30]	CRC Cn	62 62	Panel H	4	0.84	-	-	-
Chang, P.Y., et al. (2016) [30]	CRC Cn	62 62	Panel I	2	0.81	-	-	-
Liu, H., et al. (2016) [32]	CRC Cn	150 98	Panel J	2	0.88	-	87	82
Koga, Y., et al. (2010) [37] ^a	CRC Cn	206 134	Panel K	2	-	-	46	95
			Panel L	9	-	-	74	79
			Panel M	6	-	-	70	82
Choi, H., et al. (2019) [40]	CRC Cn	29 29	Panel N	2	-	-	97	38
Wu, C.W., et al. (2017) [41]	CRC Cn	29 115	Panel O	2	0.89	<0.0001	66	95

Note: p-values represent the statistical significance of AUC values. Panel A: miR-21, miR-92a; Panel B: miR-18a, miR-135b; Panel C: miR-221, miR-135b; Panel D: miR-221, miR-18a; Panel E: miR-221, miR-18a, miR-135b; Panel F: miR-20a, miR-135b; Panel G: miR-20a, miR-92a; Panel H: miR-223, miR-92a, miR-16, miR-106b; Panel I: miR-223, miR-92a; Panel J: miR-21, miR-146a; Panel K: miR-135a, miR-135b; Panel L: miR-17-92 cluster*, miR-21, miR-135; Panel M: miR-17-92 cluster* (including miR-17, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a); Panel N: miR-92a, miR-144; Panel O: miR-144-5p, miR-451a; ^a Diagnostic performance was reported only for 197 fecal samples of CRC and 119 controls. Abbreviations: Ref: Reference; No.: number; SEN: sensitivity; SPE: specificity; AUC: area under the curve; CRC: colorectal cancer; Cn: control.