Table 1.
Instrument strength per cytokine in the cis-pQTL and cis-eQTL analyses
| Cytokine | Gene | Gene ensemble | Chr | Start hg19 | End hg19 | cis-pQTL (n instruments) | pQTL (r2) | cis-eQTL (n instruments) | eQTL (r2) |
|---|---|---|---|---|---|---|---|---|---|
| activePAI | SERPINE1 | ENSG00000106366 | 7 | 100770370 | 100782547 | 1 | 0.003 | – | – |
| bNGF | NGF | ENSG00000134259 | 1 | 115828537 | 115880857 | – | – | 1 | 0.002 |
| CTACK | CCL27 | ENSG00000213927 | 9 | 34661893 | 34662689 | 3 | 0.060 | 2 | 0.041 |
| Eotaxin | CCL11 | ENSG00000172156 | 17 | 32612687 | 32615199 | 6 | 0.015 | 4 | 0.010 |
| FGFBasic | FGF2 | ENSG00000138685 | 4 | 123747863 | 123819390 | – | – | 2 | 0.002 |
| GROa | CXCL1 | ENSG00000163739 | 4 | 74735109 | 74737019 | 11 | 0.272 | 1 | 0.127 |
| HGF | HGF | ENSG00000019991 | 7 | 81331444 | 81399452 | 6 | 0.010 | – | – |
| IL-16 | IL16 | ENSG00000172349 | 15 | 81517640 | 81605104 | 18 | 0.037 | 6 | 0.031 |
| IL-18 | IL18 | ENSG00000150782 | 11 | 112013974 | 112034840 | 5 | 0.051 | 2 | 0.024 |
| IL-1a | IL1A | ENSG00000115008 | 2 | 113531492 | 113542971 | – | – | 3 | 0.003 |
| IL-1ra | IL1RN | ENSG00000136689 | 2 | 113885138 | 113891593 | 18 | 0.075 | 2 | 0.017 |
| IL-2ra | IL2RA | ENSG00000134460 | 10 | 6052657 | 6104333 | 14 | 0.260 | 4 | 0.130 |
| IL-6 | IL6 | ENSG00000136244 | 7 | 22766766 | 22771621 | 1 | 0.002 | 1 | 0.001 |
| IL-7 | IL7 | ENSG00000104432 | 8 | 79645007 | 79717758 | 1 | 0.005 | – | – |
| IL-8 | CXCL8 | ENSG00000169429 | 4 | 74606223 | 74609433 | 1 | 0.004 | 2 | 0.005 |
| IL-12p70 | IL12A | ENSG00000168811 | 3 | 159706623 | 159713806 | 1 | 0.002 | – | – |
| IL-12p70 | IL12B | ENSG00000113302 | 5 | 158741791 | 158757481 | 1 | 0.002 | – | – |
| IP-10 | CXCL10 | ENSG00000169245 | 4 | 76942269 | 76944689 | 5 | 0.020 | – | – |
| MCP-1 | CCL2 | ENSG00000108691 | 17 | 32582296 | 32584220 | 28 | 0.006 | 3 | 0.001 |
| MCP-3 | CCL7 | ENSG00000108688 | 17 | 32597235 | 32599261 | 13 | 0.289 | – | – |
| MCSF | CSF1 | ENSG00000184371 | 1 | 110453233 | 110473616 | 13 | 0.049 | 3 | 0.018 |
| MIF | MIF | ENSG00000240972 | 22 | 24236565 | 24237409 | 2 | 0.019 | 5 | 0.020 |
| MIG | CXCL9 | ENSG00000138755 | 4 | 76922623 | 76928641 | 1 | 0.011 | 2 | 0.008 |
| MIP1a | CCL3 | ENSG00000277632 | 17 | 34415603 | 34417506 | 34 | 0.217 | 1 | 0.059 |
| MIP1b | CCL4 | ENSG00000275302 | 17 | 34431220 | 34433014 | 26 | 0.147 | 3 | 0.003 |
| PDGFbb | PDGFB | ENSG00000100311 | 22 | 39619685 | 39640957 | 1 | 0.001 | – | – |
| RANTES | CCL5 | ENSG00000271503 | 17 | 34198496 | 34207377 | 1 | 0.009 | 1 | 0.009 |
| SCF | KITLG | ENSG00000049130 | 12 | 88886570 | 88974250 | 3 | 0.006 | 2 | 0.001 |
| SCGFb | CLEC11A | ENSG00000105472 | 19 | 51226605 | 51228981 | 2 | 0.016 | 1 | 0.004 |
| SeSelectin | SELE | ENSG00000007908 | 1 | 169691781 | 169703220 | 2 | 0.008 | 2 | 0.002 |
| sICAM | ICAM1 | ENSG00000090339 | 19 | 10381517 | 10397291 | 25 | 0.168 | 2 | 0.004 |
| sVCAM | VCAM1 | ENSG00000162692 | 1 | 101185196 | 101204601 | 1 | 0.003 | 1 | 0.003 |
| TNF-A | TNF | ENSG00000232810 | 6 | 31543344 | 31546112 | 2 | 0.004 | – | – |
| TNF-B | LTA | ENSG00000226979 | 6 | 31539876 | 31542100 | – | – | 1 | 0.001 |
| TRAIL | TNFSF10 | ENSG00000121858 | 3 | 172223298 | 172241297 | 46 | 0.027 | 5 | 0.006 |
| VEGF | VEGFA | ENSG00000112715 | 6 | 43737946 | 43754223 | 21 | 0.073 | 1 | 0.0004 |
activePAI active plasminogen activator inhibitor-1, bNGF beta nerve growth factor, CTACK cutaneous T-cell attracting chemokine, FGFBasic basic fibroblast growth factor, GROa growth-regulated oncogene-alpha, HGF hepatocyte growth factor, IL interleukin, ra receptor antagonist, IP-10 interferon gamma-induced protein 10, MCP1 monocyte chemotactic protein-1, MCP3 monocyte chemotactic protein-3, MCSF macrophage colony-stimulating factor, MIF macrophage migration inhibitory factor, MIG monokine induced by interferon-gamma, MIP macrophage inflammatory protein, PDGFbb platelet-derived growth factor BB, SCF stem cell factor, SCGFb stem cell growth factor beta, SeSelectin soluble E-selectin, sICAM soluble intercellular adhesion molecule, sVCAM soluble vascular cell adhesion molecule, TNF tumour necrosis factor, TRAIL TNF-related apoptosis inducing ligand, VEGF vascular endothelial growth factor