Figure 3.

GILZ expression correlates with DC activation state and functions. Several factors induce GILZ expression in DC, contributing to driving DC towards a tolerogenic state. GILZ decreases CD80 and CD86 expression, reducing their capability for activating T cells. Conversely, DC are activated in conditions of low or null GILZ expression (either by experimentally inducing GILZ silencing or in patients with respiratory allergic disease), releasing IL-12 and reducing PD-L1 expression. In addition, CD8α+ cells, the DC phenotype with the highest GILZ levels, lose the ability to exert micropinocytosis.